Here the researchers used a crude extract of the fruit hull of Garcinia mangostana L, mangosteen fruit. On the basis of
physicochemical data, the active substances were identified as alpha-mangostin and gammamangostin in the crude extract. The researchers found that alpha-Mangostin and gammamangostin may become novel types of lead compounds for histamine and serotonin receptor antagonists (fight allergies and inflammation).

Allergies & Inflammation. Researchers found that alpha-mangostin ( found in themangosteen fruit) blocked the binding of histamine to its receptors (fight allergies andinflammation).

Novel types of receptor antagonists from the medicinal plant Garcinia mangostana. [Article in Japanese] Nippon Yakurigaku Zasshi. 1997 Oct;110 Suppl 1:153P-158P. Furukawa K, Chairungsrilerd N, O hta T, Nozoe S, Ohizumi
Y. Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

A Summary of 31 Mangosteen Studies
Introduction: Narace D. Seudeal, Ph.D. is a Ph.D. in Clinical Biochemistry who refuses to accept products without the research to back them up — meaning actual clinical and scientific studies rather than weak tests that have no real relevance to the human condition. Mangosteen xanthones research is extensive and studied by Ph.D.’s, MD’s, and other research scientists from around the world.
Dr. Seudeal reviewed 31 selections of mangosteen xanthones research articles and condensed the main conclusions in an easy-to-read format with the least technical jargon as possible, yet keeping the integrity of the medical findings intact.
Remember, this is just a sampling of xanthones research. There are over 1500 papers on xanthones listed at, the National Medical Library. For hundreds of years, Asian natives used the mangosteen fruit to treat a variety of sicknesses and conditions, without any clue as to the nature of the active ingredients in their concoctions using the mangosteen fruit or why they worked. Today, because of the mangosteen xanthones research done worldwide, we can understand why the potions, preparations, and poultices used by the natives of Asia were effective enough to endure through time. 31 Mangosteen Research Studies Summarized by Narace D. Seudeal, Ph.D.

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